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Andras J. Pellionisz
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A thought leader of geometrization of neuroscience and genomics.
Geometrization of Neuroscience (1969-1989) Sparked Neurophilosophy (see career of Profs. Churchland)
Emerging Philosophy & Clinical Utilization of Unification of Neuroscience & Genomics (1989-2013) may be too fresh to similarly assess, as FractoGene just passed its first decade. (2002-2012)
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Founder of HolGenTech, Inc.
Founder of International HoloGenomics Society Owner of HelixoMetry IP Holding |
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As a domain expert in Genome Informatics, Andras Pellionisz is a cross-disciplinary scientist and technologist. With Ph.D.’s in Computer Engineering, Biology and Physics, he has 45 years of experience in Informatics of Neural and Genomic Systems spanning Academia, Government and Silicon Valley Industry. Dr. Pellionisz played a leading role in the paradigm shift from Artificial Intelligence to Neural Nets, including the establishment of the International Neural Network Society. Today, his work is foundational to HoloGenomics, the integration of 100+ years of Genetics with 60+ years of Epigenetics. In 2005, he combined interdisciplinary communities of Genomics and Information Technology when he established the International HoloGenomics Society (IHGS). Pellionisz founded HolGenTech, Inc. as a Genome Analytics company to leverage defense-validated high-performance hybrid computer hardware with a novel, fractal algorithm-based approach for genome analysis and recommendation. Based on sound genome informatics, his work sets forth new mathematical principles for proceeding soundly with full exploration of the whole genome. Dr. Pellionisz’ fractal approach to genome function is now corroborated by recently published findings about the fractal folding of DNA structure by Presidential Science Adviser Eric Lander. Dr. Pellionisz put forth the first theory of full genome (hologenome) recursive fractal iterative function, as the mathematical basis of genome regulation, presenting in Cold Spring Harbor Labs, 2009. He correctly predicted that genome regulation includes recursion in 1989. His work, since 1989, precedes by many years what is considered today’s cutting edge in genomic science. For years, Dr. Pellionisz published his research in direct opposition to mistakenly held assumptions (Junk DNA and Central Dogma) that held sway for decades. In 2002, just one year after The Human Genome Project acknowledged that a decade of research and billions of dollars failed to produce the expected 140-300 thousand "genes" in the highly repetitive genome, Dr. Pellionisz conceived FractoGene and filed US patents since 2002 (his first issued patent dated 1984). He formally published this work in 2006 before the US NIH DECODE concluded with a disposition consistent with Dr. Pellionisz’ findings: In 2008, his breakthrough research: "The Principle of Recursive Genome Function" superseded the misnomer "Junk DNA", a term widely used for 30+ years to define intergenetic material, was as widely misunderstood and dismissed until HoloGenomics. As now widely admitted, the material is critical to understanding DNA, and Dr. Pellionisz’ algorithmic formulations represent rare methods of discovery and application of the material. Pellionisz’ US career started in 1973 with a Stanford Post Doctoral Fellowship followed by a position taken in 1976 as a Research Professor of Biophysics at New York University Medical Center. Anticipating the Internet boom, he moved back to Silicon Valley to work for the US government at NASA Ames Research Center as a Senior Research Associate of the National Academy. Dr. Pellionisz was the first to provide a blueprint instruction for automated landing an F15 fighter on one wing with the Transputer parallel computer neural network. He subsequently participated in the government handover of Internet development to private industry. From 1994, he served as Chief Software Architect to several "dot com boom" Silicon Valley companies. Over the decades, Dr. Pellionisz successfully pioneered the geometrization of biology, first in neuroscience resulting in early industrial neural net applications and later in genomics, manifesting today in industrial applications for personal genomes. His efforts in the year of 2012, ending "the decade of genome uncertainty" he accomplished a geometric unification of neuroscience and genomics, and by FractoGene, the parent application of his IP-group issued on October 3rd, 2012, implements the industrialization of genomics to clinical use. |
Experience
Board of Adviser to ELOGIC Technologies, Genome Analytics Service from India-Siliconvalley in Bangalore, India,
Board of Adviser to DRC computer, a Security First Company; Leveraging Defense HPC for Genomics
Founder and President of HolGenTech, Sunnyvale, USA-Siliconvalley in California; (Informatics for the Genome Based Economy)
Director of Genome Informatics, Mitrionics, TM, Los Gatos, California
Founder of International HoloGenomics Society (Formerly PostGenetics Society)
European Union visiting Professor for Hungary (for "European Inaugural of IPGS")
Founder of FractoSoft (Software for PostGenetics, Silicon Valley, with Central European outsourcing)
Founder of Helixometry (IP portfolio holding, Silicon Valley)
Inventor and Founder of FractoGene (Fractal approach to DNA)
Chief Software Architect and Chief Intelligence Officer of several Silicon Valley Internet Companies in the dot.com boom
Founder of International Neural Networks Society (INNS)
Founding Editor of Neural Networks (publication organ of INNS)
Section Editor for Neural Networks of The Cerebellum (Springer, New York & Heidelberg)
Professor of Physiology and Biophysics, New York University Medical Center
Visiting Professor of Marburg University, Germany (Humboldt Prize for Senior Distinguished Amercian Scientists)
Visiting Professor of UMR/CNRS, College de France, Paris
Senior Research Council Associate of the National Academy of Science, USA, to NASA
PostDoctoral Fellow, University of Iowa
PostDoctoral Fellow, Stanford University
Tenured Senior Research Fellow and Doctor of Physics of the Hungarian Academy of Sciences
| List of Publications
GEOMETRIZATION OF GENOMICS; Fractal Approach to Genome Function (151) Pellionisz, A.J., Graham, R., Pellionisz, P.A., Perez, J.C. (2011) Recursive Genome Function of the Cerebellum: Geometric Unification of Neuroscience and Genomics. Invited Chapter to Springer Handbook "The Cerebellum and Cereballar Diseases" Ed. by Dr. Mario Manto. (In Press). (Abstract, References and Supplementary Material) (150) US Patent Office Issues FractoGene Patent to HolGenTech Founder Pellionisz (149) Pellionisz, A. (2011) FractoGene patent group Intellectual Property Office Action (148) Pellionisz, A. (2011) FractoGene patent group Intellectual Property Office Action (147) Pellionisz, A. (2010) Helixometry Intellectual Property Office Action (146) Pellionisz, A. (2009) From the Principle of Recursive Genome Function to Interpretation of HoloGenome Regulation by Personal Genome Computers. Cold Spring Harbor Laboratory; Personal Genomes meeting, Sept. 14-17, 2009 (144) Shapshak, P, Chiappelli, F, Commins, D, Singer E, Levine, AJ, Somboonwit, Minagar, A, Pellionisz, A. (2008) Molecular epigenetics, chromatin, and NeuroAIDS/HIV: Translational implications; Bioinformation. 3(1): 5357. PMCID: PMC2586134 Published online 2008 October 7. (archieved free full .pdf) (143) Chiappelli F, Shapshak P, Commins D, Singer E, Minagar A, Oluwadara O, Prolo P, Pellionisz AJ. (2008) Molecular epigenetics, chromatin, and NeuroAIDS/HIV: Immunopathological implications. Bioinformation. 3(1):47-52. PMCID: PMC2586137, Epub 2008 Oct 7.Click here to read (archieved free full .pdf) (142) Pellionisz, A. (2008) The Principle of Recursive Genome Function. (full pdf to view and/or save).The Cerebellum (Springer, New York & Heidelberg), Epub ahead of Print DOI 10.1007/s12311-008-9935-y, (Abstract PubMed PMID: 18566877), (archieved free full html text) (141) Pellionisz, A. (2008) FractoGene patent group Intellectual Property filed to USPTO (140) Pellionisz, A. (2007) Cerebellogenesis. In: Special Issue of "The Cerebellum" (in preparation) (139) Pellionisz, A. (2008) FractoGene patent group Intellectual Property filed to USPTO (137) Pellionisz, A. (2006) PostGenetics: Genetics beyond Genes. The journey of discovery of the function of "junk" DNA. Peer-invited and peer-reviewed Keynote lecture at "European Inaugural of the International PostGenetics Society", 12. October, 2006, Budapest, Hungary, a Satellite to the International Congress of Immunogenomics and Immunomics, pp. 219., BCII2006 (136) Simons, M. and Pellionisz, A. (2006 a) Genomics, Morphogenesis and Biophysics: Triangulation of Purkinje Cell Development, The The Cerebellum, 2006; 5(1): 27-35 (Full text .pdf to view and/or save as .pdf) Abstract: PubMed 16527761 (135) Pellionisz, A. (2005) FractoGene patent group Intellectual Property filed to USPTO (134) Pellionisz, A. (2004) FractoGene patent group Intellectual Property filed to USPTO (133) Pellionisz, A. (2004) FractoGene patent group Intellectual Property filed to USPTO (132) Pellionisz, A. (2003) FractoGene patent group Intellectual Property filed to USPTO (131) Pellionisz, A. (2003) FractoGene Design-Tool for Protein-Based Self-Assembling Nanostructures, Materials and Applications. In: Proceedings of the Symposium "Biological Nanostructures, Materials, and Applications", Invited Lecture, sponsored by the ECS New Technology Subcommittee held at the 204th Meeting of The Electrochemical Society, Orlando, FL (Peer-invited and peer-reviewed Keynote lecture) (130) Pellionisz, A. (2002) FractoGene patent group Intellectual Property filed to USPTO
(129) Pellionisz, A. (2002) Morphogenesis of the Central Nervous System: A Third of a Century (1968-2002) to Reveal the Morpho-Genesis of the Brain
(128) [1996-2001] Intellectual Property to NASA, SVNI and Silicon Valley Internet Companies not in public domain ----- SEED CONCEPT BETWEEN GEOMETRIZATION OF NEUROSCIENCE AND GENOMICS ----- NEURAL GEOMETRY: Tensor Network Theory (126) Pellionisz, A.J. (1994) From Geometrical Foundations of NN Research to Lead-Roles in Silicon Valley Information Industry in Flight Control and Infohighway Interface. Invited Lecture at Korean Neural Network Conference, Seoul, Korea (122) Pellionisz, A. J. and C. Ramos (1992) A Geometrical Approach to the Vestibular Control of Movement and Posture. Natural and Artificial Control of Hearing and Balance, Rheinfelden, Switzerland, J. Allum, eds., Elsevier (121) Pellionisz, A. J., D. L. Tomko and J. Bloedel R. (1992) Neural Geometry Revealed by Neurocomputer Analysis of Purkinje Cell Responses. Computing by Neural Systems, San Francisco, C. Ploegaert, eds., Kluever, Boston, MA, 1-5. (118) Pellionisz, A. (1991) The Geometry of Massively Parallel Neural Interconnectedness in Wired and Wireless Volume Transmission . Ch. 45. In: Volume Transmission in the Brain . Ed. by K.J.Fuxe and L. Agnati, Raven Press, New York, pp. 557-568 (117) Pellionisz, A.J. and Bloedel, JR. (1991) Functional geometry of Purkinje cell population responses as revealed by neurocomputer analysis of multi-unit recordings. Soc. Neurosci. Absts. v.21 (114) Pellionisz, AJ, Peterson, B.W., Tomko, L.D. (1990) Vestibular Head- Eye Coordination: a Geometrical Sensorimotor Neurocomuter Paradigm. in : Advanced Neurocomputing. Ed. R. Eckmiller, Elsevier, North Holland. pp.126-145. (110) Pellionisz, A (1989) About the Geometry Intrnsic to Neural Nets. International Joint Conference on Neural Nets, Washington, D.C. Vol. I. p. 711-715. (109) Pellionisz, A (1989) Fractal Geometry of Purkinje Neurons: Relationships among Metrical and Non-Metrical Neural Geometries. Soc. Neurosci. Absts. 15 (1) 180. (108) Pellionisz, A (1989) Brain Geometry: The need of Researching Association of Covariant and Contravariant Coordinates that Organize a Cognitive Space by Relating Multisensory-Multimotor Representations. Proc. of 3rd. IEEE Intern. Conf. on Neuronal Netorks, Washington, D.C. (107) Peterson, B.W., Pellionisz, A.J., Baker, J.A., Keshner, E.A. (1989) Functional Morphology and Neural Control of Neck Muscles in Mammals. Am. Zoology, 29:139-149 (106) Pellionisz, A. (1988) Vistas from Tensor Network Theory: A Horizon from Reductionalist Neurophilosophy to the Geometry of Multi-Unit Recordings. In: Computer Simulation in Brain Science (ed. by R. Cotterill), Cambridge University Press, pp. 44-73. (105) Pellionisz, A., Peterson, BW. (1988) A Tensorial Model of Neck Motor Activation. In: Control of Head Movement (eds. Peterson, BW. and Richmond, F.), Oxford University Press , pp. 178-186. (104) Pellionisz, A., Peterson, BW. (1988) Theoretical Predictions of Spatial Anisotropy of Acerebellar Dysmetria in Head Movements of Cats. Soc. Neurosci. Absts. 14/2: 1239. (103) Berthoz, A., Benhamou, M. and Pellionisz, A.J. (1988) Postural Positions Yielding Aligned Eigenvectors of Coordinate Frames Intrinsic to Vestibular and Nead-Neck Muscle Systems in Human. Soc. Neurosci. Absts. 14/2: 1235 (102) Pellionisz, A. (1988) Intelligent Decisions and Dynamic Coordination: Properties of Geometrical Representation by BGeneralized Frames Intrinsic to Neural and Robotic Systems. Proc. of 2nd IEEE Internatl. Conf. on Neuronal Networks, San Diego, Vol. 2:603-610. (101) Pellionisz, A. (1988) Coordinated Trajectory Control in Intrinsic Sensorimotor Frames. Absts. 1st. Ann. Mtg. Boston, Neural Networks, Suppl: 1:354. (100) Pellionisz A. (1988) Sensorimotor Operations: a Ground for the Co-Evolution of Brain Theory with Neurobotics and Neurocomputers. In: Proc. IEEE First Annual International Conference on Neural Networks, San Diego Vol.4:593-600. (99) Pellionisz, A. (1988) Tensorial Aspects of the Multidimensional Massively Parallel Sensorimotor Function of Neuronal Networks. In: Progress in Brain Research: Vestibulospinal Control of Posture and Movement. (ed. by O. Pompeiano and J.H.J. Allum) Progress in Brain Research, Elsevier, pp. 341-354. (98) Pellionisz, A. (1988) Tensor Geometry: A Language of Brains and Neurocomputers. Generalized Coordinates in Neuroscience and Robotics. In: Neural Computers (NATO Advanced Science Institutes Series, F (Computers and Systems Sciences Vol. 41) (ed. by R. Eckmiller and C. von Malsburg), Springer Verlag, Berlin pp. 381-391. (97) Bloedel, J.R., Tillery, S.I. and Pellionisz, A.J. Experimental-Theoretical Analysis of the Intrinsic Geometry of Limb Movements. Neurosci. Abst. 14: 952, 1988 (95) Daunicht, W. & Pellionisz, A. (1987) Spatial arrangement of the Vestibular and the Oculomotor System in the Rat. Brain Research 435. pp. 48-56. (93) Pellionisz, A.(1987) Tensor Geometry as the Mathematical Language of Neuronal Networks. Brain Theory & Foundation for Neurobotics and Neurocomputers. Proc. of IBRO II.World Congress, Neuroscience, Suppl. to Vol 22, p. S101 (92) Peterson, B.W., Baker, J.F., Pellionisz, A.J. (1987) Multidimensional Analysis of Vestibulo-Ocular and Vestibulo-Colllic Reflexes (VOR and VCR). In: Proceedings of the International Symposium on Basic and Applied Aspects of Vestibular Function, Hong Kong (89) Liverneaux, Ph, Pellionisz, A.J., Lestienne, F.G. (1987) Morpho-Anatomy and Muscular Synergy of Sub-occipital Muscles in Macaca Mulatta: Study of Head-Trunk Coordination. Proc. of IBRO II. World Congress, Neuroscience , Suppl. to Vol.22, p. S847 (88) Lestienne, F, Liverneaux, Ph. and Pellionisz, A. (1988) Morpho-anatomy of sub-occipital muscles in monkey: a tensor model of the musculo-skeletal head-neck system. Reunion Commune de la Physiological Society et de l'Association des Physiologistes, France 2 July 1988. Proc. Physiol. Soc. J. Physiol. (Lond) pp.2P (86) Lestienne, F, Liverneaux, Ph., Pellionisz, A. (1987) Role of the Superficial and Deep Neck Muscles in the Control of Monkey Head Movement: Application of the Tensor Analysis Approach. Soc. Neurosci. Absts. 13. V.1. p.372. (84) Pellionisz, A. (1987) Koordináció: Túlhatározott Központi Idegrendszeri Koordinátarendszerek Vektor-Mátrix Leirása és Tenzor Megoldása a Moore-Penrose Generalizált Inverz Segítségével. Fizikai Szemle, Budapest (83) Pellionisz, A. (1987) Tensor Network Theory of the Central Nervous System. Encyclopaedia of Neuroscience (eg. G. Adelman), Birkhauser, p. 1196-1198. (81) Pellionisz, A. (1986) Tensor Network Theory of the Central Nervous System and Sensorimotor Modeling. In: Brain Theory (eds. Palm G., & Aertsen, A.), Springer Verlag, Berlin-Heidelberg-New York, pp. 121-145 (79) Pellionisz, A. (1986) Old Dogmas & New Axioms in Brain Theory. Commentary to "Cortical Connections and Parallel Processing: Structure & Function: by D.H. Ballard". Behavioral and Brain Sciences, 9. pp. 103-104 (78) Pellionisz, AJ., Soechting, JF, Gielen, CCAM, Simpson, JI., Peterson, BW, Georgopoulos, AP. (1986) Workshop: Multidimensional Analyses of Sensorimotor Systems. Soc. Neurosci. Absts. 12, p. 1 (77) Peterson, BW. & Pellionisz, AJ. (1986) A Tensorial Model of the Kinematics of Head Movements in the Cat. Soc. Neurosci. Absts. 12, p. 684 (76) Pellionisz, A. (1986) Tensorial Relationship Found for Structural and Functional Reference Frames of Brain Function: Saccade Neurons in Monkey Utilize Frames Composed of the Eigenvectors of the Frame of Extraocular Muscles. Soc. Neurosci. Absts. 12, p. 1186 (75) Daunicht, W. & Pellionisz, A. (1986) Coordinates Intrinsic to the Semicircular Canals and the Extraocular Muscles in the Rat. Soc. Neurosci. Absts. 12, p. 1089 (74) Pellionisz, A. (1986) Tensor Model of Gaze. In: Proc. "Developments in Oculomotor Research" Gleneden Beach, Oregon, p. 52 (73) Pellionisz, A. (1986) Tensor Network Theory and its Application in Computer Modeling of the Metaorganization of Sensorimotor Hierarchies of Gaze. In: Proc. "Neuronal Networks for Computing". AIP 151, New York: American Institute of Physics. pp.339-344. (72) Daunicht, W. & Pellionisz, A. (1986) Physical Arrangement of Extraocular Muscles in the Rat. Proc. of European Neuroscience Association (71) Pellionisz, A. (1986) Az Agyműködés Tenzorelmélete (Tensor Theory of Brain Function). Proc. of "The Role of Hungarians in the Scientific and Technological Progress of the World", World Federation of Hungarians & Hungarian Academy of Sciences, Budapest (70) Pellionisz, A. (1985) Tensor Theory of Brain Function and its Applications to Sensorimotor Modeling. Brain and Behaviour Report #4. Program abstracts and summary of the meeting on "Activity Patterns of Neural Populations", (eds. Johannesma, PIM., Eggermont, JJ., van Gisbergen, JAM.), Brain and Behaviour Society, Nijmegen, The Netherlands (69) Pellionisz, A. (1985) Tensor Theory of Brain Function & its Applications to Sensorimotor Modeling. In: Proceedings of Vth Internatl. Symp. on Motor Control. 85, Varna. p. 104 (67) Pellionisz, A. (1985) Robotics Connected to Neurobiology by Tensor Theory of Brain Function. Proc.IEEE International Conf. on Systems, Man & Cybernetics. pp. 411-414 (66) Pellionisz, A. & Peterson, B.W. (1985) Tensor Models of Primary Sensorimotor Systems, such as the Vestibulo-Collic Reflex (VCR) and the Metaorganization of Hierarchically Connected Networks. Soc. Neurosci. Absts. 11. p 83 and Neck-Motor Control Systems. In: Proceedings of Annual Conference on Engineering in Medicine & Biology (65) Peterson, B.W., Baker, J., Wickland, C. & Pellionisz, A. (1985) Relation Between Neck Muscle Pulling Directions and Activity by the VCR: Experimental Test of a Tensor Model. Soc. Neurosci. Absts. 11. p. 83 (64) Peterson, BW., Baker, J., Wickland, C., & Pellionisz, A. (1985) Sensorimotor Transformation in Oculomotor (63) Graf, W., & Pellionisz, A. (1985) Morphology and a Tensor Network Model of the Three-Neuron Vestibulo-Ocular Reflex Arc in Cat. Soc. Neurosci. Abst. 11. p. 1041 (61) Pellionisz, A. (1985) Tensorial Brain Theory in Cerebellar Modeling. In: Cerebellar Functions (ed. Bloedel, J., Dichgans, J. & Precht, W.), Springer, Heidelberg, pp. 201-229 (60) Llinás, R. & Pellionisz, A. (1985) Cerebellar Function and the Adaptive Feature of the Central Nervous System. In: Reviews of Oculomotor Research. I. Adaptive Mechanisms in Gaze Control. (ed. by A. Berthoz and G. Melvill-Jones). Elsevier, Amsterdam, pp. 223-232 (59) Ostriker, G., Llinás, R. & Pellionisz, A. (1985) Tensorial Computer Model of Gaze. Oculomotor Activity is Expressed with Natural Non-Orthogonal Coordinates. Neuroscience. 14, pp. 483-500 (58) Pellionisz, A. & Llinás, R. (1985) Tensor Network Theory of the Metaorganization of Functional Geometries in the CNS. Neuroscience, 16, pp. 245-274 [pdf] (57) Ostriker, G., Pellionisz, A. & Llinás, R. (1984) Tensorial Computer Movie Display of the Metaorganization of Oculomotor Metric Network. Soc. Neurosci. Absts. 10, p. 162 (56) Pellionisz, A. (1984) Tensorial Computer Movie of the Genesis & Modification of Cerebellar Networks as Dyadic Expansions of the Eigenvectors Stored in the Inferior Olive. Soc. Neurosci. Absts. 10, p. 540 (55) Simpson, JI. & Pellionisz, A. (1984) The Vestibulo-Ocular Reflex in Rabbit as Interpreted Using the Moore-Penrose Generalized Inverse Transformation of Intrinsic Coordinates. Soc. Neurosci. Absts. 10, p. 909 (54) Llinás, R. & Pellionisz, A. (1984) La Mente in Quanto Proprieta Tensoriale dei Circuiti Cerebrali. In: Livelli di Realta, (ed. Palmarini, M.P.), Feltrinelli, Italy, pp. 191-198 (53) Pellionisz, A. (1984) Coordination: A Vector-Matrix Description of Transformations of Overcomplete CNS Coordinates and a Tensorial Solution Using the Moore-Penrose Generalized Inverse. J. Theoret. Biol. 110, pp. 353-375 [full free text .pdf] (52) Pellionisz, A., Ostriker, G. & Llinás, R. (1983) Generation and Modification of Neuronal Networks Acting as Metric Tensors: A Computer Demonstration of the Process of Organizing Sensorimotor Transformations. Soc. Neurosci. Absts. 9, p. 310 (49) McCollum, G., Pellionisz, A. & Llinás, R. (1983) Tensorial Approach to Color Vision. J. Theoret. Neurobiol. 2(1), pp. 23-28 (48) Pellionisz, A. & Llinás, R. (1982) Tensor Theory of Brain Function. The Cerebellum as a Space-Time Metric. Chapter 23. In: Competition and Cooperation in Neural Nets. Proceedings of the US-Japan Joint Seminar, held at Kyoto, Japan (ed. by S. Amari and MA Arbib), Lecture Notes in Biomathematics #45 (managing ed. Levin, S), Springer Verlag, Berlin-Heidelberg-New York, pp. 394-417. (47) Pellionisz, A. & Llinás, R. (1982) Space-Time Representation in the Brain. The Cerebellum as a Predictive Space-Time Metric Tensor. Neuroscience, 7, pp. 2949-2970 (46) Ostriker, G., Pellionisz, A. & Llinás, R. (1982) Tensor Network Theory Applied to the Oculomotor System. CNS Activity Expressed with Natural Non-Orthogonal Coordinates. Soc. Neurosci. Absts. 8, p. 155 (45) Malinow, R., Pellionisz, A. & Llinás, R (1982) Tensor Network Theory Providing a Paradigm for Motor Control of Posture and Movement in Multilegged Systems. Soc. Neurosci. Absts. 8, p. 283 (43) Pellionisz, A & Llinás, R (1981) Genesis and Modification of the Geometry of CNS Hyperspace. Cerebellar Space-Time Metric Tensor and "Motor Learning". Soc. Neurosci. Absts. 7, p. 641. (41) Pellionisz, A. & Llinás R. (1979) Cerebellar Coordination: Covariant Analysis and Contravariant Synthesis via Metric Tensor. A Tensorial Approach to the Geometry of Brain Function. Soc. Neurosci. Absts. 5, p. 105 (40) Pellionisz, A. & Llinás R. (1979) A Note on a General Approach to the Problem of Distributed Brain Function. Matrix and Tensor Quarterly, The Journal of the Tensor & Matrix Society of Great Britain. 30, pp. 48-50 (39) Pellionisz, A. & Llinás R. (1979) The Cerebellum: A Neural System with Parallel Distributed Organization. AAAS Absts., Washington, DC., p. 54 (38) Pellionisz, A. & Llinás, R. (1979) Brain Modeling by Tensor Network Theory and Computer Simulation. The Cerebellum: Distributed Processor for Predictive Coordination. Neuroscience, 4, pp. 323-348 [full free text in .pdf] (36) Pellionisz, A. (1979) Cerebellar Control Theory. In: Recent Developments of Neurobiology in Hungary, VIII. (ed. by Lissák, K.) Akadémiai Kiadó, Budapest pp. 211-243 (35) Pellionisz, A. & Llinás, R. (1978) A Formal Theory for Cerebellar Function: The Predictive Distributed Property of the Cortico-Nuclear Cerebellar System as Described by Tensor Network Theory and Computer Simulation. Soc. Neurosci. Absts. 4, p. 68 (34) Pellionisz, A. (1978) Synthesis of Fragmented Data on Neuronal Systems: A Computer Model of Cerebellum. In: Progress in Cybernetics and System Research. Vol. III. (ed. by Trappl, R., Klir, G.J. & Ricciardi, L.), John Wiley & Sons, New York, NY, pp. 411-427 [free full text .pdf] (33) Pellionisz, A. & Llinás, R. (1977) Analysis of Anuran Vestibulo-Cerebellar Control by Computer Modeling. Soc. Neurosci. Absts. 3, p. 60 (28) Pellionisz, A. & Llinás, R. (1977) Analysis of Simple and Complex Spike Generator Mechanism of Dendritic Trees: A Computer Model of Purkinje Cell. In: Proceedings of the Symposium "Neuron Concept Today", Tihany. (eds. Hámori, J., Vizi E.Sz., & Szentágothai J.), Pergamon / Akadémiai Kiadó, Budapest, pp. 195-202 (27) Pellionisz, A., Llinás, R. & Perkel, DH. (1977) Systematic Method for the Interpretation of Experimental Data within a Holistic Neuronal Circuitry: A Computer Model of the Cerebellum of Frog. In: Proceedings of the Symposium "Neuron Concept Today" , Tihany. (eds. Hámori, J., Vizi E.Sz., & Szentágothai, J.), Pergamon / Akadémiai Kiadó Budapest p. 276 (26) Pellionisz, A. (1976) Proposal for Shaping the Dynamism of Purkinje Cells by Climbing Fiber Activation. Brain Theory Newsletter, 2, pp. 2-6 (25) Pellionisz, A. & Llinás, R. (1976) Multikompartmentális Hodgkin-Huxley Kábelmodell a Purkinje Sejt Kúszórostjának Analízisére. Magyar Élettani Társaság 15. Vándorgyülésének Elödáskivonatai (Multicompartmental Hodgkin-Huxley Cable Model for the Analysis of the Climbing Fiber Response of Purkinje Cells. In: Proceedings of the 15th Annual Convention of the Society of Hungarian Physiologists.) (24) Pellionisz, A. (1976) Gipotesa Plastnichnosti Dinamizma Kletok Purkinje na Mozheckovuyu Sisthemu Koordinacii Dvizheniy. (A Hypothesis for the Plasticity of Purkinje Cells in the Cerebellar System for Coordination of Movements) In: Proceedings of IXth Symposium of Intercosmos, Budapest, p. 26. (23) Pellionisz, A. (1976) Proposal on System- and Purkinje Cell Levels for the Function of Cerebellum in Motor Control. Proceedings of the IIIrd Internatl. IUPS Symposium on Motor Control , Varna, p. 53 (22) Pellionisz, A. & Llinás, R. (1975) Simple and Complex Spike Generation in a Computer Model of Cerebellar Purkinje Cells. Soc. Neurosci. Absts, 1, p. 319. (21) Pellionisz, A. (1974) Számítógépes Szimulációs Modellezés: A Kisagykéreg Neuronhálózatának Szimulációja. (Computer Simulation Modeling: Simulation of Cerebellar Neuronal Networks. Orvos és Technika, 2, pp. 33-47 (20) Pellionisz, A. (1974) Számítógépes Szimulációs Modellezés: A Kisagykéreg Neuronhálózatának Szimulációja. In: A Számitógépek és Orvosbiológiai Alkalmazásuk. (Computer Simulation Modeling: Simulation of Cerebellar Neuronal Networks. In: Computers and their Use in Medical Biology), (Ed. by Fedina, L.), Semmelweis Orvostudományi Egyetem, Budapest, pp. 198-212 (19) Pellionisz, A. & Szentágothai, J. (1974) Dynamic Single Unit Simulation of a Realistic Cerebellar Network Model. II. Purkinje Cell Activity within the Basic Circuit and Modified by Inhibitory Systems. Brain Research, 68, pp. 19-40 (18) Pellionisz, A. (1973) Kisagykérgi Ideghálózatok Strukturo-Funkcionális Elemzése a Számítógépes Szimuláció Módszerével. Kandidátusi Értekezés. (Structuro-Functional Analysis of Cerebellar Neuronal Networks by the Use of Computer Simulation Methods., Ph.D. Thesis, Advisor: J.Szentágothai), Hungarian Academy of Sciences, Budapest, pp. 1-107 (17) Pellionisz, A. (1973) A számítógépek és orvos-biológiai alkalmazásuk. Biológiai rendszerek szimulációja. Orvos és Technika, pp.22-38 (16) Szentágothai, J. & Pellionisz, A. (1973) A Quantitative Approach to Cerebellar Cortex Histology and its Significance for Computer Studies of the Cerebellar Neuron Network. Proceedings of the IVth Internatl. Conference: de la Physique Theorique a la Biologie, Versailles, France (15) Pellionisz, A., Palkovits, M., Hámori, J. Pintér, E. & Szentágothai, J. (1973) Quantitative Comparison of the Cerebellar Synaptic Organization of Immobilized and Normal Kittens. In: International Union for Pure & Applied Biophysics: IVth International Biophysics Congress Symposium Papers 3, Puschino, pp. 381-384 (13) Pellionisz, A. & Szentágothai, J. (1973) Computer Simulation of the Cerebellar Neuronal Network: Cinematized Cerebellar Activity Model. In: International Union for Pure and Applied Biophysics: IVth International. Biophysics Congress. Symposium Papers. 4 (1), Puschino, pp. 61-62 (12) Pellionisz, A. (1972) Computer Simulation of the Cerebellar Cortex. Acta Cybernetica, 1, p. 287 (11) Pellionisz, A. (1972) Számítógéppel Készült Szimulációs Film Kisagykérgi Neuronhálózatok Müködésének Modellezésére. In: Számítástechnikai és Kibernetikai Módszerek Alkalmazása az Orvostudományban és Biológiában c. III. Kollokvium Kiadványa. (Computerized Movie Display for Simulation of Neuronal Circuits of Cerebellum. In: Proceedings of the IIIrd Colloquium on Computers and Cybernetics in Biology and Medicine), Szeged, pp. 15-23 (10) Pellionisz, A. (1972) Modelirovanie Predvaritelnoj Obrabotki Nervnoj Informacii Postupajuschei v Koru Mozecka s Pomoschu Vucislitelnih Mashin. (Modeling of the Processing of Information Arriving at the Cerebellar Cortex by Use of Digital Computer). Acta Cybernetica, 1, p. 280 (9) Pellionisz, A. (1972) Computer Simulation of the Information Preprocessing in the Input of the Cerebellar Cortex. Acta Cybernetica 1, pp. 157-169 (8) Pellionisz, A. (1971) Számítógépek az Orvosbiológiai Kutatásban. In: Számítógép Alkalmazási Területek és Lehetöségek az Orvostudományban (ed. by B. Kanyár) (Computers in Biomedical Research. In: Fields and Possibilities for Use of Computers in Medicine). Semmelweis Orvostudományi Egyetem, Budapest, pp. 84-108 (7) Pellionisz, A. (1971) A Kisagykéreg Működésének Számítógépes Szimulációja. In: Magyar Anatómusok, Hisztológusok és Embriológusok Társasága Kongresszusának Kiadványa (Computer Simulation of the Cerebellar Cortex. In: Proceedings of the Congress of Hungarian Anatomists, Histologists and Embryologists). Pécs, p. 26 (6) Pellionisz, A. (1971) A Kisagykéreg Működésének Számítógépes Szimulációja. In:Számítástechnikai és Kibernetikai Módszerek Alkalmazása az Orvostudományban és Biológiában c. III. Kollokvium Kiadványa. (Computer Model of the Cerebellar Neuronal Network. In: Proceedings of the IIIrd Colloquium on Computers and Cybernetics in Biology and Medicine), Szeged, pp. 63-78 (4) Pellionisz, A. (1970) Modelirovanie Neironuh Shetej Mozhechka pri Ispholzovanii Vicislitelhih Mashini. (Computer Modeling of Cerebellar Neuronal Nets), In: Proceedings of the International Conference on Mathematical Modeling, Varna (1) Pellionisz, A. (1967) Neuron Modellezés. Diplomaterv. Budapest Műszaki Egyetem Folyamatszabályozási Tanszék (Neuronal Modeling. MSEE Thesis, Advisor: J. Szentágothai, Dept. of Process Control and Automation, Univ. Technology, Budapest), pp. 1-74 |
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Ph.D. (Computer Engineering) |
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Biophysicist of Information Geometry of Nature. For Neural Informatics, developed Tensor Network Theory of the Cerebellum, experimentally verified and F15 Fighter plane was controlled at NASA by artificial cerebellum. For this work, received the Humboldt Prize from Germany. For Genome Informatics, he established Helixometry (2001) and submitted FractoGene Patent (2002, pending), which is the only algorithmic (fractal geometrical) interpretation of the Full Genome, including the 98.7% of "junk DNA" (in the human). As a result of Geometrization of Neuro- and Genome biology, the Cerebellum is the only part of the CNS that is mathematically explained both in its structuro-functional properties (sensorimotor metric tensor of the spacetime manifold) and in its physiological and pathological growth of its brain cells (the Purkinje neuron): the genetic code is mathematically explained from the DNA repetitive sequences in terms of fractal geometry; FractoGene Pioneered the use of computers and Nature's mathematical algorithms in neural intelligence starting 1967 in Budapest, Hungary. In the USA, started as a Stanford Postdoctoral Fellow, followed by internationally recognized accomplishments in US Academia, Government and Private Industry. Presently, Dr. Pellionisz is the Founder of HelixoMetry in Silicon Valley. Steadfast pursuit of morphogenesis of the CNS, over a third of a Century, led to breakthrough applications in Bioinformatics by FractoGene, a geometrical generalization of the gene vs junkDNA concepts. Based on fractal mathematical toolkit, "CCC on DVD" the 4th Generation Genome Toolkit & Databank, as a Service Product is offered. In Academic Research, Pellionisz, as professor of New York University was the originator of a pioneering Information Geometry approach to Neural Nets, Tensor Network Theory. TNT explains the function of 1/4 of the brain (the cerebellum) in terms of tensor analysis, the intrinsic mathematical language of Biological Neural Nets. The key paper of TNT is re-published in his book on Neurocomputing (now also available in paperback), together with a lucid encapsulation of its significance by Prof. James Anderson (who also acted lately as Chief Scientist of another Internet start-up devoted to Net Intelligence). Pellionisz' TNT, as detailed in Prof. Patricia Churchland's book comparing Pellionisz' theory to that of Francis Crick is one of the few neural net approaches that is both neurobiology-based, plus provided quantitatively verifiable predictions, which furthermore have actually been proven by independent experimental neuroscientists (see Documentation). The mathematical neural net theory and its experimental confirmation reveals how the so-called "little brain", an existing neural net accomplishes space-time coordination (46). Once the book was published, the role of geometry in Neural Nets was immediately recognized by World leaders of the field, as well as by prominent Research and Development organizations (see Documentation). Even his early opponents turned, within half a decade, into followers. Now, before a decade is out after the book has been published, former antagonists appear as brazen champions of Information Geometry, by freely adopting Pellionisz' metric tensor neural net approach to non-Euclidean natural geometries to Riemannian spaces (see Documentation). In 1989b, Pellionisz published the first fractal morphogenesis of brain cell, See also FractoGene, com. For this accomplishments in Neurocomputing, Pellionisz was Awarded by Alexander von Humboldt Prize "for Senior distinguished American Scientists" (1990, New York University also noted Humboldt Award and summarized accomplishments of its Professor), and was awarded Doctor of the Hungarian National Academy (for Thesis of Lifetime Achievements 1990). In Government R&D, Pellionisz, as a Senior Research Associate of the USA National Academy of Science to NASA, is the originator of NASA's "Flight Control by Neural Nets" initiative. The program materialized years later in 1999 by NASA flying an F15 fighter plane with neural nets. To bridge Academia, Government and Industry, Pellionisz established Silicon Valley Net Institute, which forged academic Information Geometry achievements into applications in innovative business models for the use of Internet by Private Industry and Government Projects (109-110). For Industrial Applications in Private Business, Pellionisz put in the last decade his academic foundation of Information Geometry into use in Internet Search and Categorization/Profiling/Recommendation by his Neural Net approach and 4-layer architecture (Rule Base, XML, Natural Language Processing, Neural Nets). As an Executive in a series of Silicon Valley Internet companies, Dr. Pellionisz helped validate Mr. Turing's vision half a century ago. Pellionisz served as a Principal Knowledge Engineer of Ernst & Young affiliate Kanisa in Cupertino, helping a classic "big six" establishment turn into a 21st Century Internet heavyweight, then as Principal E-Commerce Engineer at independent e-mail start-up of Fabrik, San Francisco, as it transformed into E-commerce (later ROIdirect). Subsequently, he served as Chief Intelligence Officer and Sr. Architect at several Silicon Valley Information Technology Companies (Verge, Xmarksthespot, Mindmaker). As Chief Intelligence Officer of Mindmaker, Inc. a global intelligence portfolio headquartered in Silicon Valley, with subsidiaries and offices in Asia (Singapore), Europe (U.K., Belgium, Hungary), Dr. Pellionisz gained experience in top management and business development of global software company. At Mindmaker, Dr. Pellionisz established PureMatch, a division of Mindmaker. In 2001, PureMatch, inc. became an independent Silicon Valley Spin-Off with Pellionisz as Founder and CEO, a California corporation for e-Commerce (particularly m-Commerce) Personalization, that Pellionisz divested. Subsequently, synthesizing his engineering and biology degrees, his neurocomputing expertise and experience in industrial scale global software development, Dr. Pellionisz became the Founder, CEO and COB of HelixoMetry, inc, to pursue Bioinformatics in Silicon Valley, based on the fractal mathematical "language" of DNA and "Junk DNA", FractoGene. Dr. Pellionisz in 2005 Founded "International PostGenetics Society, IPGS" - an organization to put priority #1 on (formerly) "Junk DNA", and for the "European Inaugural of IPGS" received European Union Visiting Professorship to Hungary (2006). Dr. Pellionisz is fostering development of "PostGenetics Ctr"-s in several regions, and is leading an effort in PostGenetics to a) develop proprietary pioneering software that "looking beyong Genes" calls for, b) organize regional Inaugurals of IPGS (USA, Asiapacific), c) establish publication channels for PostGenetics, d) adjusting policies of resource allocation by regional programs/governments to the priorities of the PostModern era of Genetics (beyond Genes). Support of Claims Tensor Net Theory (TNT) was proven by neurobiological research (1) Gielen, C.C.A.M. and E. J. van Zuylen.(The Netherlands) Coordination of arm muscles during flexion and supination: Application of the tensor analysis approach. Neuroscience. 17: 527-539, 1986, and (2) Peterson et al. (Chicago, IL, USA, 1985) Relation Between Neck Muscle Pulling Directions and Activity by the VCR: Experimental Test of a Tensor Model. Soc. Neurosci. Absts. 11. p. Concerning the emerging role of geometry in neuroinformatics (1990) By Eckmiller, R. In: "Parallel Processing in Neural Systems and Computers". Eckmiller, Hartmann and Hauske eds. Elsevier Science Publ. B.V (North Holland). Amsterdam.pp. 5-8 First, a "critique" then a turnaround by Arbib, M. and Amari, S.I. (1985) J. Theor. Biol. 112, 123-155 (with immediate response by Pellionisz in #57), followed by Amari, S: (1991) "Dualistic Geometry of the Manifold of Higher-Order Neurons. Neural Networks" [using covariant and contravariant metric tensors]: 4(4): 443-451, and now Amari, S. and S.Wu (1999) Improving support vector machine classifiers by modifying kernel functions. [using Riemannian metric tensors as foundation of "Information Geometry"]. Neural Networks, Vol.12, No.6 Terry Sejnowski and McNaughton adopt (20 years after) the dual tensorial approach for the hippocampus (See their Fig. 4. and references to Pellionisz' Tensor Network Theory papers). An F-15 fighter plane was flown by neural nets by NASA within a decade after Pellionisz as a Senior Research Associate of the USA National Academy of Science to NASA originated NASA's "Flight Control by Neural Nets" initiative A collection of Pellionisz' main public websites Co-workers of Pellionisz in Tensor Network Theory and Independent Schools Greatly Influenced by TNT Some samples of citations of Tensor Network Theory (html only) Citations of Tensor Network Theory (doc, pdf, ps, etc. formats) HelixoMetry, inc. was established by Dr. Pellionisz as Founder, CEO and COB as a California C corporation to solely focus on Personalized Medicine (using his 4-layer intelligence algorithm, AI, XML, NLP and Neural Nets, in genomics, microarray data-analysis, personalized drug discovery, development and recommendation). As he outlined as early as a decade ago in his NIH/NIMH/NASA/NSF "decade of the brain program" we are now at the brink that neural net technologies of non-Euclidean metrical and fractal geometries. Pellionisz studied in morphogenesis of cerebellum (1977, #30), and pioneered fractal genetic determination of Purkinje neurons (1989). This Intellectual Property in Information Technology now finds its application in deciphering the highly repetitious, self-similar, fractal-like DNA genome. In joint venture with several Intellectual Property companies (e.g. Translation Companies hitherto for Natural Languages), HelixoMetry developed an entirely new business model (4th Generation Genome Database, a CCC on DVD Service Product), bundled with FractoGene, "the new mathematical language of the Genetic Code". |